SynMiBi.

Publications.

2024

T. Vornholt, M. Mutný, G.W. Schmidt, C. Schellhaas, R. Tachibana, S. Panke, T.R. Ward, A. Krause, M. Jeschek. Enhanced sequence-activity mapping and evolution of artificial metalloenzymes by active learning. ACS Central Science 10:1357-1370, https://doi.org/10.1021/acscentsci.4c00258 (2024).

2023

S. Höllerer, C. Desczyk, R. M. Farrera, M. Jeschek. From sequence to function and back – High-throughput sequence-function mapping in synthetic biology. Curr. Op. Systems Biology 100499, https://doi.org/10.1016/j.coisb.2023.100499 (2023).

T. Vornholt, Z. Joncev, V. Sabatino, S. Panke, T.R. Ward, C. Sparr, M. Jeschek. An artificial metalloenzyme for atroposelective metathesis. ChemCatChem e202301113, https://doi.org/10.1002/cctc.202301113 (2023).

S. Höllerer, M. Jeschek. Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript. Nucleic Acids Research gkad040, https://doi.org/10.1093/nar/gkad040 (2023).

2021

T. Vornholt, F. Christoffel, M. Pellizzoni, S. Panke, T.R. Ward, M. Jeschek. Systematic engineering of artificial metalloenzymes for new-to-nature reactions. Science Advances 7:eabe4208 (2021).

2020

S. Höllerer, L. Papaxanthos, A.C. Gumpinger, K. Fischer, C. Beisel, K. Borgwardt, Y. Benenson, M. Jeschek. Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping. Nature Communications 11:3551 (2020).

T. Vornholt, M. Jeschek. The quest for xenobiotic enzymes ‐ from new enzymes for chemistry to a novel chemistry of life. ChemBioChem, 21:2241-2249 (2020).

2019

S. Wu, Y. Zhou, D. Gerngross, M. Jeschek, T.R. Ward. Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources. Nature Communications 10:5060 (2019).

2018

T. Heinisch, F. Schwizer, B. Garabedian, E. Csibra, M. Jeschek, J. Vallapurackal, V.B. Pinheiro, P. Marlière, S. Panke, T.R. Ward. E. coli surface display of streptavidin for directed evolution of an allylic deallylase. Chemical Science 9:5383–5388 (2018).

M. Jeschek, S. Panke, T.R. Ward. Artificial metalloenzymes on the verge of new-to-nature metabolism. Trends in Biotechnology 36:60-72 (2018).

before 2018

M. Jeschek, M.O. Bahls, V. Schneider, P. Marlière, T.R. Ward, S. Panke. Biotin-independent strains of Escherichia coli for enhanced streptavidin production. Metabolic Engineering 40:33-40. (2017).

M. Jeschek, D. Gerngross, S. Panke. Combinatorial pathway optimization for streamlined metabolic engineering. Current Opinion in Biotechnology 47:142-151 (2017).

M. Jeschek, S. Panke, T. R. Ward. Periplasmic screening for artificial metalloenzymes. Methods in Enzymology 580:539-556 (2016).

M. Jeschek, R. Reuter, T. Heinisch, C. Trindler, J. Klehr, S. Panke, T.R. Ward. Directed evolution of artificial metalloenzymes for in vivo metathesis. Nature 537:661-665 (2016).

M. Jeschek, D. Gerngross, S. Panke. Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort. Nature Communications 7:11163 (2016).

M. Jeschek. Engineering Escherichia coli for non-natural metabolism. Dissertation, ETH Zurich (2016).

M. Jeschek, T. R. Ward, S. Panke. Novel process to produce streptavidin and other biotin-binding proteins. European Patent Application. EP13178560.2 (2013).

MJ's Author Profile

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